In the modern world of beauty and makeup, understanding the skin’s biological processes and enhancing its natural capabilities are more focused than fast and exaggerated apparent changes. Today, in addition to covering aging signs, many aesthetic treatments like PDO thread lift are designed to activate the repair mechanisms. This scientific and sustainable approach has brought a vast popularity for those methods that are safe, minimally invasive, and based on the natural body reaction.
PDO thread treatment has found a special position in the field of beauty as an advanced nonsurgical technique. PDO thread is made of an absorbable and biocompatible material. More importantly, it activates the body biological reaction for collagen production. This property results in a long lasting treatment effect even after the threads are absorbed by the body. Therefore, PDO threads for skin laxity are considered an efficient solution. In the present content, we explain the PDO thread absorption process. Additionally, we point out the collagen response for this method as one of the main crucial properties of this method.
Biological Process of Collagen Stimulation after PDO Threads

Understanding the biological process of collagen production stimulation after using PDO threads is the main key to perceiving the effectiveness and durability of this method in beauty treatments. In contrast to many superficial treatments affecting the skin appearance only, PDO thread treatment directly involves body repair mechanisms, activating them in a controlled way.
After placing the PDO threads in certain layers of the skin, the body recognizes them as an external biocompatible object. This causes an onset of a mild and controlled inflammatory response which completely differs from injurious inflammatory reactions. This mild inflammation plays the role of a biological signal to attract cells responsible for tissue repair, especially fibroblasts, to the treatment site. Fibroblasts are key cells in the production of collagen, elastin, and other components of the extracellular matrix. This is before starting the PDO thread absorption process.
The main point is that the stimulation of collagen production is not limited to the presence of PDO threads. They are gradually absorbed by the body, while the produced biological signals by them could remain active even after starting the absorption process. In addition to producing collagen type I which is responsible for skin firmness, PDO threads could stimulate the production of collagen type III. This plays a key role for skin elasticity and overall quality.
The biological process of collagen stimulation also improves local blood flow. Consequently, it causes better supply of oxygen and nutrients to skin cells. In addition, repair processes are accelerated, providing a suitable environment for sustainable skin regeneration. Finally, the skin is structurally strengthened and is improved in terms of health and freshness.
Timeline of PDO Thread Absorption and Collagen Production
Knowing about PDO thread absorption process and the collagen production procedure plays an important role in forming realistic expectations of the results of the treatment. In contrast to many beauty methods with temporary effects, PDO threat lift has a gradual and step-by-step process to create structural changes in the skin slowly and progressively. Here, we point out these steps and their signs.
Initial days
In the first days, after placing the PDO threads in the skin, the mechanical effects of threads play the main role. Skin has the physical support of threads, possibly with a mild lift or immediate improvement in the skin firmness. At the same time, the body begins showing a controlled inflamed reaction around the threads, establishing the next steps for skin reconstruction. This is usually slight and is considered as a natural part of the treatment.
First weeks
Before starting the PDO thread absorption process, the activity of fibroblasts increases gradually. In this period, new collagens are produced around the threads paths. The apparent changes may still be subtle; however, the skin is in active reconstruction step in the microscopic stage. Gradual collagen production increases the skin firmness, evening the texture.
Second to fourth month
Now, the PDO thread absorption process starts. The threads are decomposed by the body, while the new formed collagen matrix substitutes the threads. In this period, many people find obvious improvement in firmness, freshness, and overall quality of skin. This stage is usually known as the peak of results observation.
Next months
Even after the threads are completely absorbed, the skin reconstruction process will be continued. The collagen produced in the first months evolves and forms a denser structure. This stage is of great importance because it shows that the treatment result does not depend on the presence of PDO threads, but it relies on the skin’s biological response. Now, the skin has a more natural appearance with firmer structure and healthier condition.
In general, PDO thread absorption process usually takes 6 to 8 months, while produce of collagen could last 12 months and even more.
Impact of Collagen Response on Skin Firmness and Texture
The collagen response after PDO thread lift is one of the most important factors to explain the visible improvements in skin firmness and texture. As we mentioned before, collagen as the structural backbone of the skin, has a key role in maintaining the firmness, uniformity and quality of the skin surface. In the following, we elaborate some of the most important impacts of collagen response of the PDO thread lift.
Skin strengthening
Increase in the production of collagen strengthens the dermis layer of the skin, the layer responsible for mechanical strength and resistance of the skin. After the PDO thread absorption process, as this layer thickens, the skin becomes more able to withstand the pulling forces caused by gravity and everyday movements. This structural strengthening directly increases the skin firmness, improving its loose or sagging appearance.
Improving skin texture
Collagen response also affects the skin texture significantly. Produce of new collagens reconstructs the extracellular matrix; it is a structure to hold skin cells together, ensuring the evenness of the skin surface. Improving the matrix, the skin seems smoother and softer. Thereby, the appearance of superficial lines and fine wrinkles is improved due to strengthening the collagen network.
Skin clarity and radiance
Collagen response also could affect skin clarity and radiance. Increase in collagen mostly brings local blood circulation improvement and better nutrition of skin cells. This makes, even after the PDO thread absorption process, skin seems healthier with more even color. Although the main goal of the treatment is skin firmness, enhancing the overall skin quality is considered as one of the valuable results.
It should be noted that the collagen response affects skin firmness and texture in different people differently. Factors such as age, genetics, and skin health can affect the severity of this response.
Factors Affecting Collagen Stimulation After PDO Thread Treatment

Intensity and quality of collagen response after PDO thread treatment are not the same for everyone; they are affected by a combination of individual, biological, and therapeutic factors. Although PDO threads are able to stimulate the production of collagen, the skin and body condition for each person determine how much this stimulation will be effective and will last.
Age
This is one of the most effective factors on the treatment and PDO thread absorption process. As aging, fibroblast activity and the skin’s ability to produce new collagen decreases. Younger people usually have faster and stronger collagen response. In contrast, the intensity of collagen stimulation is lower, requiring more time to show the results. This age difference directly affects the degree of firmness and improvement in skin texture after treatment.
Skin quality
The initial skin quality also plays an important role in collagen reaction. Skins damaged by environmental hazards such as sunlight, pollution, or tobacco use may show weaker reactions to the stimulation created by the PDO threads. In contrast, those skins with healthier structure usually react better with more collagen.
Lifestyle
This is another important factor for collagen stimulation even after the PDO thread absorption process. Poor nutrition, lack of protein or essential vitamins, chronic stress, and lack of sleep could disrupt skin reconstruction. On the other hand, a balanced diet, adequate water intake, avoiding smoking, and taking care of your skin provide a proper condition for collagen production. These factors affect the treatment results indirectly, but effectively.
Treatment technique
Technique and procedure of the treatment are other impactful factors. Thread insertion depth, number of threads used, and type of PDO threads all affect the intensity of collagen response. Correct placement of the threads in the appropriate layer of the skin causes collagen production mechanisms to be stimulated evenly and effectively. Conversely, improper technique could result in poor response or unpredictable outcomes. This is why the experience and skill of the doctor play crucial roles in the treatment success.
Long-Term Skin Changes Following PDO Thread Absorption

Once the PDO thread absorption process is completed, what remains in the skin is not only a temporary treatment effect, but a series of structural and functional changes that is considered as the result of the skin’s biological response to this treatment. These long-term changes are the main reason for the importance of the place of PDO thread treatment in modern skin rejuvenation approaches. These approaches focus on gradual and natural regeneration instead of sudden changes.
Collagen production
One of the most important long-term changes after PDO thread absorption is increasing the density and organization of the collagen network in the dermis layer of the skin. The collagen produced in the first months after treatment gradually becomes more mature with more regular arrangement. This denser structure causes the skin to have an internal support even after the PDO thread absorption process is completed. Consequently, the skin firmness remains and its resistance to the next drooping increases.
Overall skin improvement
Over time, skin usually seems thicker in its deeper layers. This increase in thickness indicates overall skin quality improvement instead of exaggerated or unnatural appearance. Thicker skin usually is less prone to superficial wrinkles, having a greater ability to retain moisture and flexibility. These changes are more noticeable in people with thinner skin before the treatment.
Skin texture
After PDO thread lift, the skin texture is also improved sustainably. More even skin surface, reduced roughness, and increased softness are among the changes that last for a long time. This texture improvement indicates successful regeneration of the extracellular matrix, having a key role in healthy skin appearance. In many cases, these changes cause the skin to seem younger even without a significant lift.
Skin condition
Functionally, after the PDO thread absorption process, skin usually shows better responsiveness to skin care and complementary therapies. Strengthened collagen network and improved blood circulation provide the optimal conditions for nutrient absorption and better response to care products. This enhances and remains the positive effects of treatment over the time.
The important point about the long-term changes is that they are not permanent; however, they could slow down the skin aging process. Over time and continuing the natural aging process, collagen production decreases again. However, skin that has undergone PDO Thread Treatment usually maintains better quality compared to its original condition. This difference shows that the PDO thread lift has a temporary effect; also it is considered a biological investment in skin health.
Effect of PDO Threads on Collagen making
Overall reviews show that PDO thread lift is more than a mere nonsurgical technique. Activating the skin’s natural regeneration ability, this method creates a situation in which, even after the PDO thread absorption process, the skin could strengthen its structure and resistance to aging signs. This feature makes the treatment results natural, gradual, and in harmony with the skin’s biological processes. To receive the best services for PDO thread lift contact us in Amada Med Spa. Find everything you need to reach the best results.
| Key Characteristics | Aspect |
| Controlled biological stimulation triggered by PDO thread placement | Primary Mechanism of Action |
| Mild, localized inflammatory reaction activating fibroblasts | Initial Tissue Response |
| Predominantly Type I for firmness and Type III for elasticity | Collagen Types Involved |
| Gradual absorption over approximately 6–8 months | Timeline of Thread Absorption |
| Begins within weeks and increases progressively | Onset of Collagen Production |
| Typically observed between 2–4 months post-treatment | Peak Collagen Activity |
| Improved structural support and resistance to laxity | Skin Firmness Outcome |
| Smoother, more uniform skin with enhanced softness | Texture and Surface Changes |
| Collagen remodeling may continue up to 12 months or longer | Longevity of Biological Effects |
| Age, skin quality, lifestyle, technique, and post-treatment care | Influencing Factors |
| Strengthened dermal matrix with sustained skin quality | Post-Absorption Skin Condition |
| Natural, gradual rejuvenation driven by endogenous collagen | Overall Clinical Benefit |
